Now enrolling

See if the PiNACLE trial is
right for you.

A Trial for People with Aggressive B-Cell Non-Hodgkin Lymphoma. Lymphoma is a type of blood cancer. Answer a few questions to check your eligibility.

About the PiNACLE Trial (tap to expand)

See if You May Qualify

About the PiNACLE Trial

The PiNACLE trial is testing a CAR T-cell therapy called rondecabtagene autoleucel (ronde-cel), also known as LYL314. This investigational therapy is made from your own white blood cells. The cells are collected, modified in a lab to better find and kill cancer cells, and then returned to you through an IV infusion.

The PiNACLE trial aims to:

Learn how well ronde-cel works against lymphoma
Understand its safety in people with lymphoma

The study is sponsored by Lyell Immunopharma, Inc.

Who Can Join?

You may be able to join if you:

Are 18 years or older.
Have been diagnosed with aggressive B-cell non-Hodgkin lymphoma, such as diffuse large B-cell lymphoma, transformed follicular lymphoma, or primary mediastinal large B-cell lymphoma.
Have received prior treatment including an anti-CD20 antibody (like rituximab) and chemotherapy. Have lymphoma that has returned or not responded to treatment.

Other medical requirements apply. A trial doctor will confirm whether you qualify after you complete this online pre-screener.

What Should I Expect During the Trial?

If you qualify and decide to participate, your PiNACLE trial journey would include:

Frequently Asked Questions

What is a clinical trial?

A research trial to test if a new drug is safe and effective.

What is CAR T-cell therapy?

CAR T-cell therapy is a way to treat some kinds of cancer using a person's own white blood cells. These cells, called T cells, are modified so they can better find and kill cancer cells.

What is ronde-cel?

Ronde-cel (short for rondecabtagene autoleucel), also known as LYL314, is an investigational CAR T-cell therapy being studied in PiNACLE.

Has ronde-cel been given to people before?

Yes. More than 50 people have received ronde-cel in earlier studies. Based on these early data, the PiNACLE trial was launched to further evaluate ronde-cel for potential approval.

Will it cost me anything?

The trial drug and trial-related care will be provided at no cost. Routine medical care outside the trial may still be billed to you or your insurance. In addition, you may be eligible to have travel, lodging, and other expenses covered while you're in the trial.

How long will I have follow-up visits?

You'll be followed closely for about 2 years, then yearly up to 15 years, giving you continued support from your trial team.

Can I stop if I change my mind?

Yes. Participation is always voluntary. You may leave the trial at any time.

Apply to Participate

Please fill out this form to see if you may qualify for this clinical trial and apply to participate.

About the potential trial participant:

Question 1 of 4

Q1: Are you over 18 years of age?

Click "Yes" or "No" to answer

Question 2 of 4

Q2: Have you been diagnosed with aggressive B-cell non-Hodgkin lymphoma (a blood cancer), such as:

Diffuse large B-cell lymphoma (DLBCL)
High-grade B-cell lymphoma (HGBCL)
Grade 3B follicular lymphoma (FL)
Transformed follicular lymphoma (tFL)
Primary mediastinal large B-cell lymphoma (PMBCL)

Question 3 of 4

Q3: Have you received prior treatment for lymphoma?

Question 4 of 4

Q4: Has your lymphoma returned or not responded to treatment?

Your contact info

What is your zip code?

Participant Name

Participant Email

Participant Mobile Phone Number

Best time to contact you

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I agree to the use of my health answers, including my diagnosis and treatment history, to see if I may be eligible for the PiNACLE study. Privacy Notice

I agree to receive calls, emails, or texts (which may use automated technology) about this study from Lyell Immunopharma and study sites. Not required to participate. Msg frequency varies. Msg & data rates may apply. Reply STOP to opt out.

You may withdraw your consent at any time. See details below.

How your information is used & your privacy rights

You may withdraw your consent at any time via our Participant Privacy Portal or by contacting admin@adnexi.com. Withdrawing consent does not affect the lawfulness of any processing carried out before your withdrawal.

Your information is collected by Adnexi Inc. (204 E Second Ave #327, San Mateo, CA 94401, USA) on behalf of Lyell Immunopharma for the purpose of assessing your preliminary eligibility for the PiNACLE clinical trial. If you appear to meet preliminary eligibility criteria, your contact information and health responses may be shared with the study sponsor, its contract research organization, and participating research sites to facilitate your potential enrollment. Your phone number is verified via a one-time SMS code sent by our service provider (Twilio). Your data is stored on servers located in the United States. You may withdraw your consent or request deletion of your data at any time via our Participant Privacy Portal. For full details, see our Privacy Policy.

Adnexi Inc., 204 E Second Ave #327, San Mateo, CA 94401, USA. By providing your phone number and checking the contact consent box above, you agree to receive autodialed text messages and/or calls from Adnexi Inc. at the number provided. This consent is not required to participate in the clinical trial eligibility assessment. Message frequency varies. Message and data rates may apply. Reply STOP to opt out of texts at any time.

Please keep in mind: Even if you believe you meet the eligibility criteria, joining a clinical trial is not guaranteed. Whether you're able to take part depends on a review by a qualified healthcare professional.

If you're filling this out on behalf of a person you're caring for, answer these questions about them and you'll have an option to provide your contact information as well.

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See if the PiNACLE trial is right for you.

Apply to Participate

See if the PiNACLE trial is
right for you.